This newsletter is published by Association Revenue Partners

 
 

March 19, 2024

   
 
 
 
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Is it Magic? Artificial Intelligence Integration into Clinical Cytometry Workflows

Cytometry has experienced substantial innovation through the continuous development of novel reagents, new instrumentation, and improved analyses geared towards handling multi-dimensional data of up to 30 to 40 parameters. However, cytometry assays require extensive training and expertise in data acquisition and analysis. The final interpretation relies on integration of all available information...

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Recommendations for Using Artificial Intelligence in Clinical Flow Cytometry

The authors discuss a range of critical considerations for appropriately applying AI to clinical flow cytometry, including use case identification, low and high risk use cases, validation, revalidation, computational considerations, and the present regulatory frameworks surrounding AI in clinical medicine. In particular, we provide practical guidance for the development, implementation, and suggestions for potential...

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Unveiling the Epigenetic Landscape of Plants Using Flow Cytometry Approach

Plants are sessile creatures that have to adapt constantly changing environmental circumstances. Understanding how stress-responsive genes are regulated can help us better understand how plants can adapt to changing environmental conditions. Epigenetic markers that dynamically change in response to stimuli, such as DNA methylation and histone modifications are known to regulate gene expression...

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Differential Peripheral Immune Signatures Elicited by Vegan Versus Ketogenic Diets in Humans
 
 
www.ncbi.nlm.nih.gov
 

Nutrition has broad impacts on all physiological processes. However, how nutrition affects human immunity remains largely unknown. Here we explored the impact of a dietary intervention on both immunity and the microbiota by performing...

 
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Pxpermute Reveals Staining Importance in Multichannel Imaging Flow Cytometry
 
 
www.sciencedirect.com
 

Imaging flow cytometry (IFC) is a high-throughput microscopic technique that gathers multiparametric fluorescent and morphological data from individual cells. However, fluorescent staining is time consuming, expensive, spectrally...

 
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True Volumetric Counting of CD34+ Cells with Flow Cytometry
 
 
www.sciencedirect.com
 

While the single-platform flow cytometric CD34+ cell counting method is the preferred choice to predict the yield of mobilized peripheral blood stem cells, most flow cytometers lack the ability of hematology counter analyzers to perform volumetric...

 
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Light-Field Flow Cytometry for High-Resolution, Volumetric and Multiparametric 3D Single-Cell Analysis
 
 
www.nature.com
 

Imaging flow cytometry (IFC) combines flow cytometry and fluorescence microscopy to enable high-throughput, multiparametric single-cell analysis with rich spatial details. However, current IFC techniques remain limited in their ability to reveal subcellular information with a high 3D resolution...

 
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Radiation Exposure Lymphocyte Damage Assessed by γ-h2ax Level Using Flow Cytometry
 
 
www.nature.com
 

DNA double-strand breaks (DSBs) are considered the most relevant lesions to the DNA damage of ionizing radiation (IR), and γ-H2AX foci in peripheral blood lymphocytes are regarded as an adequate marker for DSB quantitative studies. This study aimed to...

 
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FDA Clears Beckman Coulter DxFLEX Flow Cytometer
 
 
www.news-medical.net
 

Beckman Coulter Life Sciences, a global leader in laboratory automation and innovation, has received 510(k) clearance from the Food and Drug Administration (FDA) to distribute its DxFLEX Clinical Flow Cytometer in the United States. Launched...

 
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Multi-Omics and Imaging Mass Cytometry Characterization of Human Kidneys to Identify Pathways and Phenotypes Associated With Impaired Kidney Function
 
 
www.sciencedirect.com
 

Despite the recent advances in our understanding of the role of lipids, metabolites and related enzymes in mediating kidney injury, there is limited integrated multi-omics data identifying potential metabolic pathways driving impaired...

 
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Quantum Measurement Enables Single Biomarker Sensitivity in Flow Cytometry
 
 
www.nature.com
 

We present the first unambiguous experimental method enabling single-fluorophore sensitivity in a flow cytometer using quantum properties of single-photon emitters. We use a quantum measurement based on the second-order coherence...

 
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